Evaluation of Interval Times From Onset to Reperfusion in Patients Undergoing Endovascular Therapy in the Interventional Management of Stroke III Trial
Identifieur interne : 000310 ( Canada/Analysis ); précédent : 000309; suivant : 000311Evaluation of Interval Times From Onset to Reperfusion in Patients Undergoing Endovascular Therapy in the Interventional Management of Stroke III Trial
Auteurs : Mayank Goyal [Canada] ; Mohammed A. Almekhlafi [Canada, Arabie saoudite] ; LIQIONG FAN [États-Unis] ; Bijoy K. Menon [Canada] ; Andrew M. Demchuk [Canada] ; Sharon D. Yeatts [États-Unis] ; Michael D. Hill [Canada] ; Thomas Tomsick [États-Unis] ; Pooja Khatri [États-Unis] ; Osama O. Zaidat [États-Unis] ; Edward C. Jauch [États-Unis] ; Muneer Eesa [Canada] ; Tudor G. Jovin [États-Unis] ; Joseph P. Broderick [États-Unis]Source :
- Circulation : (New York, N.Y.) [ 0009-7322 ] ; 2014.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (traitement médicamenteux), Accident vasculaire cérébral (étiologie), Activateur tissulaire du plasminogène (administration et posologie), Activateur tissulaire du plasminogène (usage thérapeutique), Délai jusqu'au traitement (), Facteurs temps, Femelle, Fibrinolytiques (administration et posologie), Fibrinolytiques (usage thérapeutique), Flux de travaux, Humains, Injections veineuses, Mâle, Procédures endovasculaires (), Reperfusion (), Thrombose (), Thrombose (imagerie diagnostique), Thrombose (traitement médicamenteux), Tomodensitométrie, Transfert de patient.
- MESH :
- administration et posologie : Activateur tissulaire du plasminogène, Fibrinolytiques.
- imagerie diagnostique : Thrombose.
- traitement médicamenteux : Accident vasculaire cérébral, Thrombose.
- usage thérapeutique : Activateur tissulaire du plasminogène, Fibrinolytiques.
- étiologie : Accident vasculaire cérébral.
- Pascal (Inist)
- Accident cérébrovasculaire, Délai jusqu'au traitement, Facteurs temps, Femelle, Flux de travaux, Humains, Injections veineuses, Mâle, Pathologie cérébrovasculaire, Cardiopathie coronaire, Infarctus, Pathologie de l'appareil circulatoire, Evaluation, Intervalle, Procédures endovasculaires, Reperfusion, Temps, Reperfusion, Homme, Malade, Thrombose, Tomodensitométrie, Transfert de patient, Voie endovasculaire, Traitement, Conduite à tenir, Essai clinique, Myocarde, Appareil circulatoire, Cardiologie.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Cardiology, Cardiovascular disease, Cerebrovascular disease, Circulatory system, Clinical management, Clinical trial, Coronary heart disease, Endovascular Procedures (methods), Endovascular route, Evaluation, Female, Fibrinolytic Agents (administration & dosage), Fibrinolytic Agents (therapeutic use), Human, Humans, Infarct, Injections, Intravenous, Interval, Male, Myocardium, Patient, Patient Transfer, Reperfusion, Reperfusion (methods), Stroke, Stroke (drug therapy), Stroke (etiology), Thrombosis (complications), Thrombosis (diagnostic imaging), Thrombosis (drug therapy), Time, Time Factors, Time-to-Treatment (statistics & numerical data), Tissue Plasminogen Activator (administration & dosage), Tissue Plasminogen Activator (therapeutic use), Tomography, X-Ray Computed, Treatment, Workflow.
- MESH :
- chemical , administration & dosage : Fibrinolytic Agents, Tissue Plasminogen Activator.
- complications : Thrombosis.
- diagnostic imaging : Thrombosis.
- drug therapy : Stroke, Thrombosis.
- etiology : Stroke.
- methods : Endovascular Procedures, Reperfusion.
- statistics & numerical data : Time-to-Treatment.
- chemical , therapeutic use : Fibrinolytic Agents, Tissue Plasminogen Activator.
- Female, Humans, Injections, Intravenous, Male, Patient Transfer, Time Factors, Tomography, X-Ray Computed, Workflow.
Abstract
Background-Meaningful delays occurred in the Interventional Management of Stroke (IMS) III trial. Analysis of the work flow will identify factors contributing to the in-hospital delays. Methods and Results-In the endovascular arm of the IMS III trial, the following time intervals were calculated: stroke onset to emergency department arrival; emergency department to computed tomography (CT); CT to intravenous tissue plasminogen activator start; intravenous tissue plasminogen activator start to randomization; randomization to groin puncture; groin puncture to thrombus identification; thrombus identification to start of endovascular therapy; and start of endovascular therapy to reperfusion. The effects of enrollment time, CT angiography use, interhospital transfers, and intubation on work flow were evaluated. Delays occurred notably in the time intervals from intravenous tissue plasminogen activator initiation to groin puncture (median 84 minutes) and start of endovascular therapy to reperfusion (median 85 minutes). The CT to groin puncture time was significantly shorter during working hours than after. Times from emergency department to reperfusion and groin puncture to reperfusion decreased over the trial period. Patients with CT angiography had shorter emergency department to reperfusion and onset to reperfusion times. Transfer of patients resulted in a longer onset to reperfusion time compared with those treated in the same center. Age, sex, National Institutes of Health Stroke Scale score, and intubation did not affect delays. Conclusions-Important delays were identified before reperfusion in the IMS III trial. Delays decreased as the trial progressed. Use of CT angiography and endovascular treatment in the same center were associated with time savings. These data may help in optimizing work flow in current and future endovascular trials.
Url:
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000748
- to stream PascalFrancis, to step Curation: 003E84
- to stream PascalFrancis, to step Checkpoint: 000908
- to stream Main, to step Merge: 005831
- to stream Pmc, to step Corpus: 000D24
- to stream Pmc, to step Curation: 000C99
- to stream Pmc, to step Checkpoint: 001392
- to stream PubMed, to step Corpus: 002499
- to stream PubMed, to step Curation: 002489
- to stream PubMed, to step Checkpoint: 002489
- to stream Ncbi, to step Merge: 001F56
- to stream Ncbi, to step Curation: 001F56
- to stream Ncbi, to step Checkpoint: 001F56
- to stream Main, to step Merge: 003093
- to stream Main, to step Curation: 005530
- to stream Main, to step Exploration: 005530
- to stream Canada, to step Extraction: 000310
Links to Exploration step
Pascal:14-0200429Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Evaluation of Interval Times From Onset to Reperfusion in Patients Undergoing Endovascular Therapy in the Interventional Management of Stroke III Trial</title><author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Almekhlafi, Mohammed A" sort="Almekhlafi, Mohammed A" uniqKey="Almekhlafi M" first="Mohammed A." last="Almekhlafi">Mohammed A. Almekhlafi</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Faculty of Medicine, King Abdulaziz University</s1><s2>Jeddah</s2><s3>SAU</s3><sZ>2 aut.</sZ></inist:fA14><country>Arabie saoudite</country><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Liqiong Fan" sort="Liqiong Fan" uniqKey="Liqiong Fan" last="Liqiong Fan">LIQIONG FAN</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1><s2>Charleston</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charleston</wicri:noRegion></affiliation></author><author><name sortKey="Menon, Bijoy K" sort="Menon, Bijoy K" uniqKey="Menon B" first="Bijoy K." last="Menon">Bijoy K. Menon</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M." last="Demchuk">Andrew M. Demchuk</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D." last="Yeatts">Sharon D. Yeatts</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1><s2>Charleston</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charleston</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D." last="Hill">Michael D. Hill</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Tomsick, Thomas" sort="Tomsick, Thomas" uniqKey="Tomsick T" first="Thomas" last="Tomsick">Thomas Tomsick</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Neurology and Radiology, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Neurology and Radiology, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author><author><name sortKey="Zaidat, Osama O" sort="Zaidat, Osama O" uniqKey="Zaidat O" first="Osama O." last="Zaidat">Osama O. Zaidat</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Radiology, Medical College of Wisconsin</s1><s2>Milwaukee</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Milwaukee</wicri:noRegion></affiliation></author><author><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C." last="Jauch">Edward C. Jauch</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Emergency Medicine, Medical University of South Carolina</s1><s2>Charleston</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charleston</wicri:noRegion></affiliation></author><author><name sortKey="Eesa, Muneer" sort="Eesa, Muneer" uniqKey="Eesa M" first="Muneer" last="Eesa">Muneer Eesa</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G." last="Jovin">Tudor G. Jovin</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Stroke Institute, University of Pittsburgh Medical Center</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P." last="Broderick">Joseph P. Broderick</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Neurology and Radiology, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0200429</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0200429 INIST</idno><idno type="RBID">Pascal:14-0200429</idno><idno type="wicri:Area/PascalFrancis/Corpus">000748</idno><idno type="wicri:Area/PascalFrancis/Curation">003E84</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000908</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000908</idno><idno type="wicri:doubleKey">0009-7322:2014:Goyal M:evaluation:of:interval</idno><idno type="wicri:Area/Main/Merge">005831</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128892</idno><idno type="RBID">PMC:4128892</idno><idno type="wicri:Area/Pmc/Corpus">000D24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D24</idno><idno type="wicri:Area/Pmc/Curation">000C99</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C99</idno><idno type="wicri:Area/Pmc/Checkpoint">001392</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001392</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002499</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002499</idno><idno type="wicri:Area/PubMed/Curation">002489</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002489</idno><idno type="wicri:Area/PubMed/Checkpoint">002489</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002489</idno><idno type="wicri:Area/Ncbi/Merge">001F56</idno><idno type="wicri:Area/Ncbi/Curation">001F56</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F56</idno><idno type="wicri:doubleKey">0009-7322:2014:Goyal M:evaluation:of:interval</idno><idno type="wicri:Area/Main/Merge">003093</idno><idno type="wicri:Area/Main/Curation">005530</idno><idno type="wicri:Area/Main/Exploration">005530</idno><idno type="wicri:Area/Canada/Extraction">000310</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evaluation of Interval Times From Onset to Reperfusion in Patients Undergoing Endovascular Therapy in the Interventional Management of Stroke III Trial</title><author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Almekhlafi, Mohammed A" sort="Almekhlafi, Mohammed A" uniqKey="Almekhlafi M" first="Mohammed A." last="Almekhlafi">Mohammed A. Almekhlafi</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Faculty of Medicine, King Abdulaziz University</s1><s2>Jeddah</s2><s3>SAU</s3><sZ>2 aut.</sZ></inist:fA14><country>Arabie saoudite</country><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Liqiong Fan" sort="Liqiong Fan" uniqKey="Liqiong Fan" last="Liqiong Fan">LIQIONG FAN</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1><s2>Charleston</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charleston</wicri:noRegion></affiliation></author><author><name sortKey="Menon, Bijoy K" sort="Menon, Bijoy K" uniqKey="Menon B" first="Bijoy K." last="Menon">Bijoy K. Menon</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M." last="Demchuk">Andrew M. Demchuk</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D." last="Yeatts">Sharon D. Yeatts</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1><s2>Charleston</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charleston</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D." last="Hill">Michael D. Hill</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Tomsick, Thomas" sort="Tomsick, Thomas" uniqKey="Tomsick T" first="Thomas" last="Tomsick">Thomas Tomsick</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Neurology and Radiology, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Neurology and Radiology, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author><author><name sortKey="Zaidat, Osama O" sort="Zaidat, Osama O" uniqKey="Zaidat O" first="Osama O." last="Zaidat">Osama O. Zaidat</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Radiology, Medical College of Wisconsin</s1><s2>Milwaukee</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Milwaukee</wicri:noRegion></affiliation></author><author><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C." last="Jauch">Edward C. Jauch</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Emergency Medicine, Medical University of South Carolina</s1><s2>Charleston</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charleston</wicri:noRegion></affiliation></author><author><name sortKey="Eesa, Muneer" sort="Eesa, Muneer" uniqKey="Eesa M" first="Muneer" last="Eesa">Muneer Eesa</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Departments of Radiology and Clinical Neurosciences, Calgary Stroke Program, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G." last="Jovin">Tudor G. Jovin</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Stroke Institute, University of Pittsburgh Medical Center</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P." last="Broderick">Joseph P. Broderick</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Departments of Neurology and Radiology, University of Cincinnati</s1><s2>Cincinnati, OH</s2><s3>USA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cincinnati, OH</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Circulation : (New York, N.Y.)</title><title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title><idno type="ISSN">0009-7322</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Circulation : (New York, N.Y.)</title><title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title><idno type="ISSN">0009-7322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiology</term><term>Cardiovascular disease</term><term>Cerebrovascular disease</term><term>Circulatory system</term><term>Clinical management</term><term>Clinical trial</term><term>Coronary heart disease</term><term>Endovascular Procedures (methods)</term><term>Endovascular route</term><term>Evaluation</term><term>Female</term><term>Fibrinolytic Agents (administration & dosage)</term><term>Fibrinolytic Agents (therapeutic use)</term><term>Human</term><term>Humans</term><term>Infarct</term><term>Injections, Intravenous</term><term>Interval</term><term>Male</term><term>Myocardium</term><term>Patient</term><term>Patient Transfer</term><term>Reperfusion</term><term>Reperfusion (methods)</term><term>Stroke</term><term>Stroke (drug therapy)</term><term>Stroke (etiology)</term><term>Thrombosis (complications)</term><term>Thrombosis (diagnostic imaging)</term><term>Thrombosis (drug therapy)</term><term>Time</term><term>Time Factors</term><term>Time-to-Treatment (statistics & numerical data)</term><term>Tissue Plasminogen Activator (administration & dosage)</term><term>Tissue Plasminogen Activator (therapeutic use)</term><term>Tomography, X-Ray Computed</term><term>Treatment</term><term>Workflow</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (traitement médicamenteux)</term><term>Accident vasculaire cérébral (étiologie)</term><term>Activateur tissulaire du plasminogène (administration et posologie)</term><term>Activateur tissulaire du plasminogène (usage thérapeutique)</term><term>Délai jusqu'au traitement ()</term><term>Facteurs temps</term><term>Femelle</term><term>Fibrinolytiques (administration et posologie)</term><term>Fibrinolytiques (usage thérapeutique)</term><term>Flux de travaux</term><term>Humains</term><term>Injections veineuses</term><term>Mâle</term><term>Procédures endovasculaires ()</term><term>Reperfusion ()</term><term>Thrombose ()</term><term>Thrombose (imagerie diagnostique)</term><term>Thrombose (traitement médicamenteux)</term><term>Tomodensitométrie</term><term>Transfert de patient</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Fibrinolytic Agents</term><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term><term>Fibrinolytiques</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Thrombosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Thrombosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stroke</term><term>Thrombosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Thrombose</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Endovascular Procedures</term><term>Reperfusion</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Time-to-Treatment</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Fibrinolytic Agents</term><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Thrombose</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Activateur tissulaire du plasminogène</term><term>Fibrinolytiques</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Patient Transfer</term><term>Time Factors</term><term>Tomography, X-Ray Computed</term><term>Workflow</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Accident cérébrovasculaire</term><term>Délai jusqu'au traitement</term><term>Facteurs temps</term><term>Femelle</term><term>Flux de travaux</term><term>Humains</term><term>Injections veineuses</term><term>Mâle</term><term>Pathologie cérébrovasculaire</term><term>Cardiopathie coronaire</term><term>Infarctus</term><term>Pathologie de l'appareil circulatoire</term><term>Evaluation</term><term>Intervalle</term><term>Procédures endovasculaires</term><term>Reperfusion</term><term>Temps</term><term>Reperfusion</term><term>Homme</term><term>Malade</term><term>Thrombose</term><term>Tomodensitométrie</term><term>Transfert de patient</term><term>Voie endovasculaire</term><term>Traitement</term><term>Conduite à tenir</term><term>Essai clinique</term><term>Myocarde</term><term>Appareil circulatoire</term><term>Cardiologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background-Meaningful delays occurred in the Interventional Management of Stroke (IMS) III trial. Analysis of the work flow will identify factors contributing to the in-hospital delays. Methods and Results-In the endovascular arm of the IMS III trial, the following time intervals were calculated: stroke onset to emergency department arrival; emergency department to computed tomography (CT); CT to intravenous tissue plasminogen activator start; intravenous tissue plasminogen activator start to randomization; randomization to groin puncture; groin puncture to thrombus identification; thrombus identification to start of endovascular therapy; and start of endovascular therapy to reperfusion. The effects of enrollment time, CT angiography use, interhospital transfers, and intubation on work flow were evaluated. Delays occurred notably in the time intervals from intravenous tissue plasminogen activator initiation to groin puncture (median 84 minutes) and start of endovascular therapy to reperfusion (median 85 minutes). The CT to groin puncture time was significantly shorter during working hours than after. Times from emergency department to reperfusion and groin puncture to reperfusion decreased over the trial period. Patients with CT angiography had shorter emergency department to reperfusion and onset to reperfusion times. Transfer of patients resulted in a longer onset to reperfusion time compared with those treated in the same center. Age, sex, National Institutes of Health Stroke Scale score, and intubation did not affect delays. Conclusions-Important delays were identified before reperfusion in the IMS III trial. Delays decreased as the trial progressed. Use of CT angiography and endovascular treatment in the same center were associated with time savings. These data may help in optimizing work flow in current and future endovascular trials.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Canada</li><li>États-Unis</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name></region><name sortKey="Almekhlafi, Mohammed A" sort="Almekhlafi, Mohammed A" uniqKey="Almekhlafi M" first="Mohammed A." last="Almekhlafi">Mohammed A. Almekhlafi</name><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M." last="Demchuk">Andrew M. Demchuk</name><name sortKey="Eesa, Muneer" sort="Eesa, Muneer" uniqKey="Eesa M" first="Muneer" last="Eesa">Muneer Eesa</name><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D." last="Hill">Michael D. Hill</name><name sortKey="Menon, Bijoy K" sort="Menon, Bijoy K" uniqKey="Menon B" first="Bijoy K." last="Menon">Bijoy K. Menon</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Almekhlafi, Mohammed A" sort="Almekhlafi, Mohammed A" uniqKey="Almekhlafi M" first="Mohammed A." last="Almekhlafi">Mohammed A. Almekhlafi</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Liqiong Fan" sort="Liqiong Fan" uniqKey="Liqiong Fan" last="Liqiong Fan">LIQIONG FAN</name></noRegion><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P." last="Broderick">Joseph P. Broderick</name><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C." last="Jauch">Edward C. Jauch</name><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G." last="Jovin">Tudor G. Jovin</name><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><name sortKey="Tomsick, Thomas" sort="Tomsick, Thomas" uniqKey="Tomsick T" first="Thomas" last="Tomsick">Thomas Tomsick</name><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D." last="Yeatts">Sharon D. Yeatts</name><name sortKey="Zaidat, Osama O" sort="Zaidat, Osama O" uniqKey="Zaidat O" first="Osama O." last="Zaidat">Osama O. Zaidat</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Canada/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000310 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Canada/Analysis/biblio.hfd -nk 000310 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Canada
|étape= Analysis
|type= RBID
|clé= Pascal:14-0200429
|texte= Evaluation of Interval Times From Onset to Reperfusion in Patients Undergoing Endovascular Therapy in the Interventional Management of Stroke III Trial
}}
| This area was generated with Dilib version V0.6.38. |  |